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DIABETES TYPE II
Type-II diabetes mellitus is insulin-resistant diabetes and it accounts for 90-95% of all diabetes cases. Experimental animal models reproduce the pathogenesis and complications associated with this disease in humans. SIA has the experience and expertise in diabetes type II transgenic animal models and diabetes type II animal model induced by high fat diet. For free consultation on model selection and study design, please contact us.
Treatment can be delivered by a variety of methods including regular delivery routes or implantation of specialized devices, therapeutic cells or scaffolds. Cell therapy and scaffolds can be implanted orthotopically into intramesenteric site.
Samples can be isolated for further analyses including histology, serum and tissue biomarker analyses, gene expression and more. Please refer to our in-vitro services section for more information on ex-vivo services offered by SIA.
DB/DB MOUSE MODEL
The metabolic abnormalities demonstrated by the db/db mouse are due to a defect in leptin signaling resulting from a point mutation in the gene for the leptin receptor. This defect affects hypothalamic responses, leading to the development of hyperphagia and obesity. Db/db Mouse model is characterized by early hyperinsulinemia with marked hyperglycemia progressing with age to slowly developing islet failure.
OB/OB MOUSE MODEL
Ob/Ob mice are deficient in the hormone leptin, which plays a major role in regulating body energy efficiency and satiety. Obesity, hyperphagia, hyperglycemia, glucose intolerance, and elevated plasma insulin are all characteristic features of the ob/ob mouse model of type II diabetes . The ob/ob model of diabetes is also characterized by poor wound healing.