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Science In Action Ophthalmology (SIAO)

SIAO is the ophthalmic branch of Science In Action Ltd located in the Weizmann Science Park in Israel.

SIAO has developed in-house expertise in a variety of ophthalmic diseases, among them Non-infectious Uveitis. Autoimmune and inflammatory uveitis are a group of potentially blinding intraocular inflammatory diseases that arise without a known infectious trigger and are often associated with immunological responses to unique retinal proteins. Uveitis is generally classified by anatomical location, anterior uveitis affects the front of the eye, intermediate and posterior uveitis affect the back of the eye and panuveitis affects all parts of the eye. Uveitis is an under-diagnosed and under-recognized medical condition that causes ocular pain and loss of vision.  In the United States, about 10-22% of the cases of severe visual handicap are attributed to this group of disorders.

SIAO’s services in Non-infectious Uveitis encompass in-vivo and in-vitro studies including pharmacokinetics, safety pharmacology, toxicology and efficacy trials, ex-vivo tissue culture services, in-vitro ELISA studies, flow-cytometry analysis. SIAO has extensive experience in various routes of administration including direct injection into the eye.

Preclinical models of Uveitis 

 Endotoxin-Induced Uveitis (EIU)

 Experimental Autoimmune Uveitis (EAU)  

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