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Lupus model


Systemic lupus erythematosus (SLE) is a severe systemic chronic autoimmune disease and NZB/W F1 mice are commonly used to study this disease. NZB/WF1 mice spontaneously develop severe lupus-like phenotypes comparable to that of lupus patients. These lupus-like phenotypes include lymphadenopathy, splenomegaly, elevated serum antinuclear autoantibodies (ANA) and immune complex-mediated glomerulonephritis (GN) that becomes apparent at 5-6 months of age, leading to kidney failure and death at 10–12 months of age.

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