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Inflammatory Bowel Disease (IBD)

Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract with rising incidence worldwide. The main forms of IBD are Crohn's disease and ulcerative colitis, chronic relapsing diseases for which there is still no cure. IBD patients suffer from abdominal pain, rectal bleeding, diarrhea, and weight loss. Histopathological signs include leukocyte infiltration, pronounced epithelial hyperplasia, depletion of mucin secreting goblet cells and finally ulceration. Although the etiology of IBD is not completely understood, it has become clear that genetic, microbial, and environmental factors all play a role.

SIA's induced and spontaneous mouse models of acute and chronic intestinal inflammation are invaluable tools for the preclinical evaluation of drug candidates for IBD.

Therapeutic agents can be tested during various period of disease induction to determine prophylactic and therapeutic efficacy.

 DSS induced IBD (acute and chronic)

 TNBS induced IBD  

 Oxazalone induced IBD  

 T-cell induced IBD  

 IL-10-deficient mouse model of IBD  

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