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Rheumatoid Arthritis (RA) 

Rheumatoid arthritis (RA) is an inflammatory disorder that affects approximately 1% of the adult population worldwide. It is characterized by systemic and local inflammation that leads to cartilage and bone destruction. Rodent models of arthritis are extensively used to study pathogenesis of disease and to evaluate potential anti-arthritic agents for clinical use. The two of the most widely used RA models for efficacy studies are the collagen-induced arthritis (CIA) and adjuvant induced arthritis (AIA).  Additionally, the

collagen antibody-induced arthritis (CAIA) model offers a robust and rapid screening model.

 Collagen-induced arthritis (CIA)

 Collagen antibody-induced arthritis (CAIA)  

 Adjuvant-induced arthritis (AIA)  

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